Description
Wpp Anadrol 50mg represents a specific formulation of oxymetholone, a potent synthetic anabolic-androgenic steroid (AAS). Its chemical name is 17β-hydroxy-2-(hydroxymethylene)-17α-methyl-5α-androstan-3-one, and it carries the CAS number 434-07-1. The compound features a 17α-alkylated structure, and this modification allows for oral bioavailability by reducing first-pass metabolism. However, this same structural feature contributes significantly to its hepatotoxicity. Anadrol-50 was originally approved by the FDA prior to January 1, 1982, but the brand name product is now discontinued in the United States. The Philippine FDA maintains an export-only registration for oxymetholone 50mg tablets under the brand name OXYPOLON
.
Mechanism of Action and Research Applications
Oxymetholone exerts its primary effects through binding to and activating the androgen receptor (AR)
. As a 17α-alkylated derivative of testosterone, it decreases oxidation of the molecule, which slows its metabolism and permits effective oral administration. The compound significantly increases muscle mass, partly due to a high level of water retention. However, the drug also suppresses the gonadotropic functions of the pituitary gland and may exert a direct effect upon the testes
.
Researchers have explored the compound for several therapeutic applications. The FDA has approved oxymetholone for treating anemias caused by deficient red cell production, including acquired aplastic anemia, congenital aplastic anemia, myelofibrosis, and hypoplastic anemias due to myelotoxic drugs
. The recommended daily dose ranges from 1 to 5 mg/kg of body weight, and response often requires a minimum trial of three to six months. Additionally, researchers have studied oxymetholone for HIV-associated wasting, antithrombin III deficiency, and pediatric growth impairment
.
Critical Safety Concerns and Toxicity
Despite its research and therapeutic potential, Wpp Anadrol 50mg carries severe and well-documented safety risks.
Hepatotoxicity: Oxymetholone is associated with significant drug-induced liver injury (DILI). The FDA mandates black box warnings for peliosis hepatitis, a condition where liver tissue is replaced with blood-filled cysts, which can lead to life-threatening liver failure or intra-abdominal hemorrhage
. Liver cell tumors, both benign and malignant, have also occurred, and fatal hepatic coma has been documented in patients receiving oxymetholone. Cholestatic jaundice represents the most important hepatic side effect. Recent research has demonstrated that oxymetholone elevates serum ALT and AST levels, induces oxidative stress by increasing malondialdehyde (MDA) and depleting reduced glutathione (GSH), and upregulates pro-inflammatory genes such as TNF-α and NF-κB
.
Blood Lipid Changes: Blood lipid changes associated with increased risk of atherosclerosis include decreased high-density lipoprotein (HDL) and increased low-density lipoprotein (LDL)
.
Other Adverse Effects: Androgenic side effects include acne, hirsutism, hair loss, clitoral/phallic enlargement, vocal changes, and gynecomastia
. Long-term use may cause testicular atrophy and hormonal disruption
.
Regulatory Status and Prohibition
Wpp Anadrol 50mg is a strictly controlled substance in most countries. The DEA has assigned oxymetholone to Schedule III (non-narcotic)
. The World Anti-Doping Agency (WADA) lists oxymetholone under Anabolic Agents, and its use in athletic competition is strictly forbidden. A metabolite of oxymetholone has resulted in a two-year sanction for a bobsled athlete and a four-year ban for a rugby league player. The FDA has discontinued the brand name Anadrol-50 in the United States
.
Conclusion
In summary, Wpp Anadrol 50mg is a potent research compound with a well-characterized mechanism of action via androgen receptor activation. It has demonstrated efficacy in treating anemias and muscle-wasting conditions. However, its significant potential for severe hepatotoxicity, peliosis hepatitis, liver tumors, blood lipid changes, and Schedule III controlled status make it a high-risk substance. Researchers must treat it with extreme caution and adhere strictly to safety protocols.
Internal Links (Hypothetical for a research chemical website):
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/products/wpp-anadrol-50mg/: View our research-grade Anadrol.
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/research-education/anabolic-steroids-guide/: Learn about the science of anabolic steroids.
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/research-education/liver-toxicity-research/: Explore research on hepatotoxicity in AAS.
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/blog/androgen-receptor-pathway/: Deep dive into androgen receptor signaling.
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/faq/research-compounds/: Frequently asked questions about research compounds.
External Links:
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DailyMed (Anadrol-50 Label): https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4b9c6c34-9cb2-4d70-b70e-c7ce2fda4212
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FDA Orange Book (Anadrol-50 Discontinued): https://www.accessdata.fda.gov/scripts/cder/ob/results_product.cfm?Appl_No=016848&Appl_Type=N
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USADA (Oxymetholone Sanction): https://www.usada.org/sanction/manteo-mitchell-receives-doping-sanction-arbitrator/
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Philippine FDA Export Certificate: https://verification.fda.gov.ph/EXPORT_ONLY_REG_CERTview.php?showdetail=&cert_number=CDRR-ERC-30
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Sport Integrity Australia (Oxymetholone): https://www.sportintegrity.gov.au/what-we-do/anti-doping/substance-education/oxymetholone
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