Description
Testosterone Propionate is a synthetic androgen ester. Its chemical formula is C22H32O3. The CAS number is 57-85-2. It acts as an androgen receptor agonist. In humans, its Ki is 0.25 nM. The propionate ester gives a relatively short duration of effect. This differs from longer testosterone esters like cypionate or enanthate. The compound appears as a white crystalline powder. It does not dissolve in water. However, it dissolves readily in oils.
Pharmacokinetic Profile
Doctors administer Testosterone Propionate via deep intramuscular injection. Its half-life is approximately 10-20 minutes. The propionate ester provides rapid testosterone release. Consequently, clinical dosing requires more frequent administration. Typically, patients receive 25-50 mg two to three times weekly. This dosing schedule maintains stable hormone levels for hormone replacement therapy. Therefore, this short-acting profile suits specific clinical needs better than longer esters.
Approved Therapeutic Uses
Physicians use Testosterone Propionate for several conditions. First, it treats primary or secondary male hypogonadism. Second, it addresses delayed male puberty in adolescents. Third, it serves as palliative treatment for advanced breast cancer. This application applies to postmenopausal women specifically.
A 2025 clinical study demonstrated another use. Researchers used it preoperatively in hypospadias patients. The dose was 2 mg/kg. Consequently, the study showed increased penile dimensions. Importantly, patients experienced only minor side effects.
Regulatory Status Worldwide
The FDA no longer approves Testosterone Propionate for U.S. sale. Nonetheless, it remains available in other countries. Specifically, China and Taiwan still permit its use. Chinese manufacturers include Zhejiang Xianju Pharmaceutical. Guangzhou Baiyunshan Mingxing also produces it. The drug requires a prescription in China. Furthermore, the Taiwanese FDA label carries cardiovascular warnings.
Unigen Brand and Sourcing Details
Unigen Life Sciences claims WHO-GMP and FDA-approved manufacturing. The company has registered offices throughout Asia. However, the brand’s regulatory status remains debated. Forum users report mixed experiences with this brand. Some users found the product effective. They cited significant testosterone effects. Conversely, others questioned the brand’s Thai FDA registration. Importantly, these reports are anecdotal. They require independent verification.
Safety and Side Effect Profile
Testosterone Propionate carries significant risks. Common side effects include acne, aggression, and injection site reactions. More serious events include heart attack, stroke, and thrombosis. Prolonged use suppresses natural testosterone production. Therefore, patients need post-cycle therapy. The drug is contraindicated in several conditions. These include prostate cancer, male breast cancer, and pregnancy.
Internal and External Links
Internal Resources
Visit our Research Chemical Library for related androgens. Explore our Guide to Androgen Receptors. Review our Safety Protocols and Regulatory Compliance FAQ. Find our Comparison of Testosterone Esters useful.
External Resources
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[PubChem]: View chemical data for CAS 57-85-2 at PubChem.
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[NCI]: Find clinical definitions at the National Cancer Institute.
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[NIH]: Access research articles at PubMed.
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[NMPA]: Check Chinese regulatory status at NMPA.
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[IUPHAR/BPS]: View pharmacological data at the Guide to Pharmacology.
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[Hims]: Read safety perspectives at Hims.
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